To build a wheel for your setuptools based project:

python setup.py bdist_wheel

The wheel will go to dist/yourproject-<tags>.whl.

If you want to make universal (Python 2/3 compatible, pure Python) wheels, add the following section to your setup.cfg:

universal = 1

To convert an .egg or file to a wheel:

wheel convert youreggfile.egg

Similarly, to convert a Windows installer (made using python setup.py bdist_wininst) to a wheel:

wheel convert yourinstaller.exe